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Nutrition · Guide · 7 min read

Can Red Onions Help Fight Cancer? What the Research Shows

Could red onions play a role in cancer prevention? This article explores research into quercetin and other compounds found in red onions, including laboratory findings involving colon cancer cells, and looks at their potential health benefits and ways to include them in a balanced diet.

Medically reviewed by Dr Abdulla El-Hossami, Group Chief Medical Officer · Sep 29, 2026Published Feb 1, 2022
Red Onions on the ground
Red Onions Help in Fighting Cancer

Red onions are rich in quercetin, a flavonoid that has shown antioxidant and anti-inflammatory properties in laboratory research. Scientists are also studying its potential role in cancer prevention and treatment.

Researchers at the University of Guelph found that one variety of Ontario-grown red onion showed particularly strong effects against colon cancer cells in laboratory experiments. While initial findings show promise, researchers need to conduct further studies to determine whether the results of lab experiments can be replicated in humans.

In the basic review of analyzing how successful Ontario-developed onions are at killing malignant growth cells, the University of Guelph analysts have observed that not all onions are equivalent. Of all the five types of onions grown in Ontario, the ruby red variety; came on top.

Onions contain several naturally occurring compounds, including quercetin and other flavonoids, that have attracted interest for their potential health effects.

What Are Flavonoids

Flavonoids are phytonutrients and occur naturally in different food items we consume. These groups of natural substances have variable phenolic structures. Naturally occurring substances known for their beneficial effects on health are present in many fruits, vegetables, barks, grains, stems, roots, flowers, wind, and tea.

Various groups of people have made several efforts to extract and isolate flavonoids from these food items. Flavonoids have anti-inflammatory effects and can protect the body cells from oxidative damage that leads to causing diseases. Dietary antioxidants, also known as natural antioxidants, can help prevent various ailments such as diabetes, cardiovascular disease, cognitive diseases, and cancer.

Result Of Research

Researchers have revealed that red onion has significant degrees of quercetin; additionally, high measures of anthocyanin enhance the searching properties of quercetin atoms.

Anthocyanin is instrumental in giving tone to foods grown from the ground, so it’s a good idea that the red onions, which are haziest in shading, would have the most disease-battling power.

Published in Food Research International, the study tested extracts from five different onion varieties against colon cancer cells in the laboratory. The red onion variety produced the strongest effects among those tested.

The researchers observed effects on pathways involved in cancer-cell growth and cell death. However, these findings came from laboratory experiments and do not establish that eating red onions has the same effect in people.

Could Onion Extracts Have a Future Role in Cancer Research?

These discoveries follow a new report by specialists on a novel extraction strategy that dispenses with the utilization of synthetics, making the quercetin found in onions more appropriate for utilization.

Solvents used in other extraction techniques can leave a harmful build-up that can be ingested into food.

This new technique that we tried is powerful. It just uses super-warmed water in a compressed compartment. Fostering a substance-free extraction technique is significant. The researchers suggested that the extraction method could potentially support further research into concentrated onion-derived compounds.

Need To Do More on Red Onion Study for Cancer Treatment

Scientists propose the development of a chemical-free extraction method for onions to harness their cancer-fighting properties in nutraceuticals and pills. Currently, onions serve as a preventive measure when added to salads and burgers. To maximize the benefits, experts recommend utilizing the outer layers of onions that have a higher flavonoid concentration. Furthermore, food products like baked goods or juice may incorporate onion extract, or it may be sold in pill form as a natural treatment option for cancer.

People have used onions for a long time to prevent and protect against various diseases. For instance, in 1918, a family that placed onions in every room of their house managed to avoid the influenza pandemic. Similarly, in the 14th century, people believed that onions protected against the bubonic plague. Both ancient Egyptians and Greeks utilized onions, with the former using them in burials for pharaohs and the latter consuming them as part of their Olympic preparation diets. Today, onions are a staple ingredient in cuisines across the globe, along with their close relatives such as garlic, leeks, scallions, and shallots.

Benefits Of Red Onions on Health

Originally red onions were cultivated in Turda in Romania, Tropea in Italy, and Wethersfield in the USA. They are also called purple onions and add color and flavor to many dishes.

There are many health benefits of red onions due to the presence of the antioxidant quercetin in them. Studies have found that this substance helps fight inflammation and boosts the immune system. You can list the different red onion health benefits thus.

  • Antibacterial action – Research has shown that red onions help kill various bacteria and inhibit the growth of many microbes. More research is necessary to know how onion affects the bacteria in the human body.
  • Cancer risk – Some observational research has found associations between onion consumption and lower risk of certain cancers. However, these studies cannot establish that onions themselves prevent cancer.
  • Digestive Health – Onions contain fructooligosaccharides, which can act as prebiotics and support beneficial gut bacteria. They pass on to the large intestine without undergoing digestion from the small intestine and feed the healthy bacteria and aid the preventive measure.
  • Bone health – Animal and human studies have supported the idea that onions may help prevent osteoporosis. In another study on women nearing their menopause, it got noted that those who consumed onions daily; had greater bone density. It is an encouraging result, as older women are more prone to osteoporosis.

Nutrition

Onions are rich in manganese, copper, vitamin b6, vitamin c, and biotin, besides having antioxidants. A half cup of chopped red onions contains the following nutrients.

  • Calories – 32
  • Protein – 1 gm
  • Fat – 0 gm
  • Carbohydrates – 7 gm
  • Fiber -1 gm
  • Sugar – 3 gm

Onions And Food Safety

Onions do have a high-antimicrobial property and are one of the least likely veggies to harbor bacteria. Yet it is advisable to store a cut onion in the fridge.

Synopsis:

Ontario-developed red onions are the best at killing colon cancer cells, contrasted with different kinds of onions. It is because of the onions’ significant degrees of quercetin and anthocyanin. As a feature of this task, the analysts are likewise quick to foster a non-poisonous method for separating quercetin from onions making it more appropriate for utilization.

Red onions are a versatile and flavorful vegetable that can not only enhance the taste of your meals but also potentially reduce the risk of cancer. With high levels of quercetin, a potent antioxidant, red onions possess anti-inflammatory and cancer-fighting properties. Including red onions as part of a varied, balanced diet can provide beneficial plant compounds such as quercetin. Early laboratory research into these compounds is promising, but more research is needed to determine whether they can help prevent or treat cancer in people.

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