Ovarian Cancer is difficult to detect in its early stages. At that time, there are rarely any symptoms, and not until an advanced stage is there an effective screening process. As a result, most women discover too late that they have the disease when it had already spread to other areas of the body like the pelvis or abdomen. By that time, surgeries and traditional cancer treatments like chemotherapy are no longer effective.

However, researchers discovered that there could be a way to detect Ovarian Cancer early. A recent research uncovered that the majority of Ovarian Cancer begin as precancerous lesions in the fallopian tubes, thin tunnels where eggs travel from the ovaries to the uterus.

MSK gynecologic oncologist and surgeon, Kara Long Roche, explains how this advancement is likely to improve the detection of Ovarian Cancer in women.

 

Cause and Effect: How did researchers observe that Ovarian Cancer started in the Fallopian Tubes?

For over a decade, a high number of women who had high risk mutations for Ovarian Cancer, such as BRCA1/2, have taken preventative surgery. The procedure called salpingo-oophorectomy, removes the ovarian and fallopian tubes. Pathologists, who spent time studying the tissues, found abnormal cells within the fallopian tubes scientifically named Serous Tubal Intraepithelial Carcinomas (STIC). Consequently, a theory was formed that these abnormal cells are the very simple cause of some Ovarian Cancer. In summary, finding these cells could lead way to early detection of Ovarian Cancer. However, more research was needed.

 

Linking STIC to Ovarian Cancer

Pathologists are able to use sophisticated tools such as genomic sequencing to analyse STIC cells which are the silent warning signs of Ovarian Cancer. Their analysis discovered that these cells harbour many shared genetic characteristics and molecular similar to the most common form of Ovarian Cancer, the High-Grade Serous Carcinoma (HGSC) . Ovarian Cancer statistics show that this is accountable for some 75% of Ovarian Cancers.

In November 2017, a study supported these findings. A mathematical model was used to calculate the correlation between STIC lesions and the development of Ovarian Cancer. The outcome of the study was that the development of STIC cells occurs between six to six years and a half, which leaves a huge amount of time for detecting Ovarian Cancer.

Verita Life is pleased to learn of the research on the relationship between STIC cells of the fallopian tubes and the development of Ovarian Cancer. This research now allows us to detect Ovarian Cancer through professionals searching for abnormal cells in the fallopian tube, enabling us to make quicker decisions to intervene medically and prevent the onset of Ovarian Cancer. Verita Life is a leading, Bangkok based hospital specialising in alternative cancer treatments and offering safe and effective, integrative care. Get in touch with us here.