Insulin Potentiated Therapy (IPT) is an alternative form of cancer treatment that uses insulin in addition to a lower dosage of chemotherapy. It is sometimes referred to as low-dose chemotherapy. It is a safer and gentler form of treatment especially for aggressive cancers, such as Lung Cancer and Colon Cancer, as well as other chronic degenerative diseases.

As a cancer treatment, IPT uses about 10% to 25% of the normal dosage of chemotherapy drugs. This means that the usual side effects of conventional chemotherapy drugs such as liver damage, nausea, hair loss, and constipation, almost never occur.

The Origin of Insulin Potentiated Therapy

Insulin Potentiated Therapy was invented in 1932 by Donato Perez Garcia to treat Syphilis. It was further developed by his son and grandson – who also patented IPT. In 1940, this invention by Garcia, a native of Mexico, was reported as being 100 percent effective for the treatment of Neurosyphilis. The therapy did not require any special equipment and was significantly cost effective. To this day, its economic significance compares to no other form of cancer treatment.

It was first used as cancer treatment in 1945.

The word “potentiate” simply means that one substance – in this case insulin – boosts the effectiveness of another – chemotherapy.

In IPT, insulin is introduced into the patient’s blood which drops their blood sugar level. Other blood cells are able to switch to fat metabolism. However, the cancer cells rely on sugar metabolism and so they go on full “starvation” mode with the low blood sugar levels. They, then, open up to let in as much sugar as they can; leaving them vulnerable.

A small dose of the chemotherapy drug is administered followed quickly by sugar water – to prevent hypoglycaemia. The extremely permeable cancer cells take in the chemotherapy drugs in an attempt to take in glucose from the blood.

Because of the insulin’s ability to better target cancer cells, the amount of chemotherapy needed is greatly reduced. Thus, the side effects of chemotherapy are greatly reduced. The chemotherapy becomes much more potent (hence, Potentiation).

Role of Sugar and Insulin in Insulin Potentiation Therapy

Sugar feeds all cells in the human body, even cancer cells. Therefore it is possible to take advantage of this clink in the cells’ armour to fight cancer cells.

Insulin is responsible for delivering glucose from the bloodstream, across cell membranes and into the cells. It is usually released into the bloodstream in response to a meal, and attaches itself to the receptors on the cell. This makes the cell membrane permeable enough to allow nutrients (glucose) into the cell.

Cancer cells have up to 20 times more insulin receptors on their surface than normal cells. Therefore, they take up more sugar than normal cells. Insulin Potentiated Therapy exploits this increased need for sugar during cancer treatment. For instance, during PET scans to find cancerous cells, radioactive agent mixed with sugar water is used. The cancer cells take up a lot of the sugar and consequently the radioactive agent and appear as a mass on the scan image.

When treating cancer with IPT the same principle applies but instead of a radioactive agent, chemotherapy drug is used.

Other than delivery of glucose to the tumour cells, insulin carries out other functions that are significant in fighting the cancer cells:

  • Insulin influences the intracellular metabolism of the tumour cells leading to an increase in the number of cells in stage S. At this stage the cells are highly sensitive to specific chemotherapy drugs.
  • Increased permeability of the cellular membranes caused by insulin leads to an increase in the quantity of antitumor agents in the cells.
  • The large number of insulin receptors on tumour cells allows the predominance of the previous mentioned functions.

Insulin Potentiated Therapy Case Study

A clinical study by Christo Damyanov, MD, of the Medical Centre for Integrative Medicine, the team observed the progression of16 patients with metastasis Prostate Cancer. The patients had undergone bilateral castration, androgenic blockade, yet the disease was progressing aggressively. During the treatment no side effects were observed. After the therapy, complete response, partial response and stabilisation was observed in 67 percent of the participants, and 33 percent showed progression.

In recent years there has been a significant progression of metastasis tumours of the prostate gland despite the efficacy of the standard androgen deprivation therapy used. This progression has come to be referred to as Castration Resistant Prostate Cancer (CRPC).

The patients were required to provide objective and subjective data for progression of the disease after surgical castration, androgenic therapy, and androgenic withdrawal. A pre-treatment evaluation of the patients was conducted to include bone scan, physical exam, disease history, prostate-specific antigen (PSA), Karnofsky performance status (KPS), Beretta evaluation, urinalysis, and chest radiographs.

During the trial, eight patients were given insulin in combination with Cyclophosphamide, Epirubicin, and Vinblastine. The other eight participants were treated with insulin combined with Docetaxel. The protocol was administered in six applications in every five-day interval, then the intervals increased to four applications in 10 days, 2, 3, and more weeks. The therapy consisted of no more than 24 IPT applications.

Objective response to the treatment was measured using PSA levels and bone scan results. The results showed complete response in 33 percent of the participants, partial response in 11 percent, 22 percent stabilized, and progression in 33 percent.

Changes in quality of life were reported using the Beretta Questionnaire. More than 50 percent decrease in symptomatic index is observed in 10 participants. Improved quality of life was recorded even for patients whose PSA levels were not encouraging.

The mean duration of remission in patients with complete response was 17 months. While toxicity was monitored using the criteria given by the World Health Organisation (WHO).

No significant side effects were reported during the treatment, and no lethal cases occurred. The most common side effects were light weakness and sleepiness on the treatment day. Some patients reported nausea and vomiting after the procedure. Blood transfusion was necessary before and during treatment for patients with low starting haemoglobin.

According to Damyanov, IPT treatment provides a real opportunity for resolving the problem of toxicity associated with maximum doses of chemotherapy.

How Does Insulin Potentiated Therapy Work?

When going for their IPT appointments, patients are asked to fast for at least 12 hours prior. The goal is to lower the blood sugar levels.

At the appointment, an IV with insulin is administered into the patients’ blood stream. The medical team monitor the blood glucose levels as they drop from the normal range of 80 to 100 mg/dl to about 40 to 60mg/dl. This usually takes 20 to 40 minutes, therefore the patient needs to be comfortable.

As the blood sugar levels drop, the patients will begin to experience symptoms of mild hypoglycaemia: mild perspiration, thirst, hunger, drowsiness, and increased heartbeat rate.

At this point, the cells are fully permeable so the chemotherapy drugs are added to the IV.

A large dose of concentrated glucose follows the drugs into the patients’ blood. The patients will also drink high sugar beverage to reverse the hypoglycaemia. The symptoms rapidly disappear and blood sugar levels are restored.

The IPT treatment procedure would typically last between one and a half hours to two hours.

At the beginning of the treatment, doctors may schedule one or two therapy sessions a week. The aggressiveness of the cancer and how the patients react to the treatment, inform the decision of whether the spacing of the sessions will be reduced. The schedule may eventually be reduced to one session month and then one every three months. This scheduling is not cast on stone; it is just a guide on what is expected.

Other complementary therapies such as Herbal Medicines, Metabolic Treatments, Wellness & Education, Personalised Anticancer Diet, or Deep-tissue Massage could be used alongside IPT. They help in detoxification, boost the patients’ immune system, and promote overall wellness.

Benefits Of Low Dose Chemotherapy

A small dose of the chemotherapy drugs is used; about 10 to 20 percent of the normal dosage. Hence the name low dose chemotherapy.

The therapy drugs directly target the cancerous cells which reduces the toxic levels that get to healthy cells. The patients have fewer almost insignificant side effects. Conventional chemotherapy uses large doses of drugs so that adequate amounts can be absorbed by the cells in order to work. The unused drugs severely damage healthy cells and the patient’s immune system suffers most.

IPT helps in the transport of drugs across the blood-brain barrier. The barrier restricts the flow of drugs between the blood and the extracellular fluid in the central nervous system. This is one of the factors of chemotherapy failure in central nervous system tumours.

The therapy is thought to change the patients’ long term blood chemical composition for the better. After studying the effect of IPT treatment on blood chemistry, Dr Perez Garcia came to the conclusion that the changes in the body’s biological terrain made it less hospitable to disease. This effect could last long after the treatment is over.

IPT is said to help in detoxification. When the cells are fully permeable, matter go in and out of the cell. This allows toxins out of the cells into the blood where they can easily leave the body.

Possible Side Effects Of IPT

There is always the immediate risk of severe hypoglycaemia.

The use of lower doses of chemotherapy is alleged to cause potential drug resistance, which could render future treatments at conventional doses ineffective.

However, the benefits of IPT far outweigh its possible side effects.

Customisation Of IPT

One other significantly important aspect of IPT is that it doesn’t follow the cookie cutter approach used in conventional oncology. The health care providers take into account the uniqueness of cases and the patients’ response to different medication before prescribing a treatment protocol. IPT is used to treat a wide variety of cancer; however a patient with Colon Cancer will follow a different protocol from one with Ovarian Cancer.

The medical practitioners will first draw blood to test the patient’s sensitivity to chemotherapy drugs and complementary homeopathic and natural substances. The goal is to determine the cocktail of drugs and remedies that work for each individual patient before administering the protocol.

IPT also follows a more holistic approach to treatment. IPT providers acknowledge that when a patient is declared cancer-free, that is the first step of a slow healing process. The intention is to eliminate the cancer and keep it from returning.

For a complete healing process, the patients need to maintain a particular regimen for some time while their bodies learn to take control again. Complementary therapies create a cancer-hostile terrain in the body and retrain the body’s ability to fight cancer on its own.

A whole range of complementary therapies available: Herbal Medicines, Metabolic Treatments, Wellness & Education, Personalised Anticancer Diet, and Deep-tissue Massage are well tolerated by the body. When combined with other treatment options such as Insulin Potentiated Therapy, they achieve stronger immune systems and improved quality of life.

The strides made towards the achievement of a wholesome cancer treatment through IPT have also rolled over to the treatment of arthritis, infectious, respiratory, cardiovascular, and neurological diseases. The slight modification to standard medication could help the medication act like super drugs, benefiting millions of patients the world over.

Proponents of Insulin Potentiated Therapy strongly believe that any chemotherapy procedure that does not suppress or damage the immune system should be pursued. A concerted attack on cancer cells using several approaches stands a better chance of success as opposed to one primary line of attack.

In Damyanov’s  words: “A certain advantage of the method along with its effectiveness is the significant improved quality of life of the treated patient.”

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